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KMID : 0366220130480040274
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Korean Journal of Hematology
2013 Volume.48 No. 4 p.274 ~ p.281
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Sequential chemotherapy followed by radiotherapy versus concurrent chemoradiotherapy in patients with stage I/II extranodal natural killer/T-cell lymphoma, nasal type
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Lee Ji-Eun
Kim Chul-Yong
Park Young-Je
Lee Nam-Kwon
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Abstract
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Background:
The purpose of this report is to summarize our clinical experience of patients with stage I/II extranodal natural killer (NK)/T-cell lymphoma, nasal type, treated using sequential chemotherapy followed by radiotherapy (SCRT) or concurrent chemoradiotherapy (CCRT).
Methods:
Forty-three patients with stage I/II extranodal NK/T-cell lymphoma, nasal type, who re-ceived SCRT (16 patients) or CCRT (27 patients) were included in the present analysis.
Results:
The median follow-up time was 39 months (range, 4?171 months) for all patients, 77 months (range, 4?171 months) for the SCRT group, and 31 months (range, 6?132 months) for the CCRT group. There were no statistically significant differences between the SCRT and CCRT groups with regard to the 3-year progression-free survival (PFS) (56% vs. 41%, P=0.823) and 3-year overall survival (OS) (75% vs. 59%, P=0.670). Univariate analysis revealed that patients with tumors confined to the nasal cavity and patients achieved com-plete remission had better PFS and OS rates, regardless of the treatment sequence. Multivariate analysis revealed that patients with tumors confined to the nasal cavity and patients aged ≤60 years had better OS rates.
Conclusion:
The effect of SCRT and CCRT are similar in terms of survival outcomes of patients with stage I/II extranodal NK/T-cell lymphoma, nasal type. Our results show that tumors con-fined to the nasal cavity and an age ≤60 years were associated with a better prognosis.
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KEYWORD
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Extranodal NK/T-cell lymphoma, Nasal type, Chemoradiotherapy, Treatment outcome
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